Contribution of clumping factor B to pathogenesis of experimental endocarditis due to Staphylococcus aureus.

نویسندگان

  • J M Entenza
  • T J Foster
  • D Ni Eidhin
  • P Vaudaux
  • P Francioli
  • P Moreillon
چکیده

Staphylococcus aureus Newman with an insertion mutation in clfB, the gene encoding clumping factor B, only marginally decreased infection rate (P>0.05) in rats with experimental endocarditis. In contrast, clfB complementation on a multicopy plasmid significantly increased infectivity (P<0.05) over the deleted mutants. Although clfB could affect endovascular infection, its importance in experimental endocarditis was limited.

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عنوان ژورنال:
  • Infection and immunity

دوره 68 9  شماره 

صفحات  -

تاریخ انتشار 2000